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Estrogen Effects on Abdominal Skeletal Muscle Fibroblasts in Inguinal Hernia Mouse Model [ATAC-Seq]

ABSTRACT: Humanized aromatase mice spontaneously develop hernias caused by fibrosis of lower abdominal skeletal muscle. To understand the estrogen action leading to herniation, fibroblasts were isolated and cultured under estrogen-replete and deplete conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE226860 | GEO | 2025/03/19

REPOSITORIES: GEO

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Estrogen Effects on Abdominal Skeletal Muscle Fibroblasts in Inguinal Hernia Mouse Model [RNA-Seq]

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Predicting Ventral Hernia Recurrence Through Genomic Profiling: An Observational Study

Project description:Patients with a history of recurrent ventral hernias (n=10) were compared with a control group (n=8) using high-throughput microarrays. Skin and fascia samples (taken away from the site of the ventral hernia) were analyzed from both groups. Our experiments show distinct genetic profiles between the skin and fascia of recurrent ventral hernia patients as compared to controls. There were also a great number of statistically significant genes in the skin as compared to the fascia. The functions of the genes in the skin were diverse and included wound healing, transcription regulation, and immunology. The genes in the fascia, however, were more specific concentrating primarily on immunology, regulation of gene expression and cellular metabolism, and development. Total RNA extracted from skin and fascia of patients with a history of recurrent ventral hernias and a control group. There were no replicates for the same source material for the same patient.

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