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Shift from androgen to estrogen action causes fibrosis, abdominal muscle atrophy, and inguinal herniation in males

ABSTRACT: Local biosynthesis of estrogen in lower abdominal skeletal muscle tissue leads to estrogen receptor-α-mediated fibrosis, muscle atrophy, and inguinal hernia. We used microarrays to detail the gene expression after aromatase expression in lower abdominal muscle tissue and identify distinct classes of up-regulated or down-regulated genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE92748 | GEO | 2018/11/14

REPOSITORIES: GEO

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