The intracellular domain of amyloid precursor protein induces the dynamic change of the gene expression profile in P19 cells.

ABSTRACT: As previously reported (Neuroscience letters 444(2008)127-131), we established embryonic carcinoma P19 cell line expressing the intracellular domain of APP (AICD). Although neurons could be differentiated from these cell lines with RA treatment, expression of AICD gave rise to neuron-specific apoptosis. To identify the genes that are involved in this cell death, we evaluated changes of gene expressions that was induced by AICD through this process of cell death. The expression profiles of almost forty thousands transcripts were monitored by DNA microarrays.

ORGANISM(S): Mus musculus

PROVIDER: GSE22690 | GEO | 2010/07/14

SECONDARY ACCESSION(S): PRJNA128295

REPOSITORIES: GEO