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Gene expression analysis of WT Th17 versus STAT4 deficient Th17 cells from EAE mice

ABSTRACT: The purpose of this study is to compare transcriptional profiles of WT and STAT4-deficient Th17 cultured cells from mice with experimental autoimmune encephalomyelitis (EAE) using RNA sequencing. WT and STAT4 deficient splenocytes from EAE immunized mice were cultured with MOG peptide under Th17 conditions for three days, and then total RNA was extracted from CD4 T cells for sequencing. Differential gene expression was determined using the DESeq2 algorithm. These data reveal a previously unrecognized role for STAT4 in Th17 gene expression and function.

ORGANISM(S): Mus musculus

PROVIDER: GSE227049 | GEO | 2023/03/30

REPOSITORIES: GEO

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