Transcriptomics

Dataset Information

0

Title: An IL-23-STAT4 Axis Regulates Classical Dendritic Cell Expansion and Function in Experimental Autoimmune Encephalomyelitis


ABSTRACT: The signal transducer and activator of transcription 4 (STAT4) promotes protective immunity and autoimmunity downstream of pro-inflammatory cytokines including IL-12 and IL-23. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), Stat4-/- mice are resistant to the development of inflammation and paralysis. Here, we examined cell-type requirements and found that in addition to T cells, STAT4 is required in dendritic cells for development of EAE. Deficiency of STAT4 in CD11c-expressing cells resulted in decreased T cell priming and inflammation in the CNS. EAE susceptibility was recovered following adoptive transfer of wild type bone marrow-derived DC to mice with STAT4-deficient DCs, but not adoptive transfer of STAT4- or IL-23R-deficient DCs. Single cell RNA-seq identified STAT4-dependent genes in DC subsets that paralleled a signature in MS patient DCs. Together, these data define a novel IL-23/DC/STAT4 pathway in DCs that could be a key to novel therapeutic targets in MS.

ORGANISM(S): Mus musculus

PROVIDER: GSE243202 | GEO | 2024/07/17

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-05-01 | E-GEOD-45122 | biostudies-arrayexpress
2013-05-01 | GSE45122 | GEO
2015-07-31 | GSE50779 | GEO
2009-01-13 | GSE14386 | GEO
2015-07-31 | E-GEOD-50779 | biostudies-arrayexpress
2013-03-07 | E-GEOD-43956 | biostudies-arrayexpress
2013-03-07 | E-GEOD-43957 | biostudies-arrayexpress
2022-06-23 | GSE200901 | GEO
2017-03-28 | GSE97035 | GEO
2024-02-28 | GSE240707 | GEO