Genomics

Dataset Information

0

The effect of a BCCA-free diet on 2W pressure overload-induced H3K23-propionyl [BCAA-free-2W-TAC-ChIP-Seq]

ABSTRACT: Identifying branched-chain amino acid (BCAA) oxidation enzymes in the nucleus led us to predict that they are a source of propionyl-CoA that could be utilized for histone propionylation and, thereby, regulate gene expression. To investigate this and its effect on the development of cardiac hypertrophy and failure, we applied pressure overload on the heart in mice maintained on a diet with standard levels of BCAA (BCAA-control) versus a BCAA-free diet. The former was associated with an increase in H3K23-propionyl (H3K23Pr) at the promoters of upregulated genes [e.g., cell signaling and extracellular matrix (ECM) genes] and a decrease at the promoters of downregulated genes [e.g., electron transfer complex (ETC I-V) and metabolic genes]. Intriguingly, the BCAA-free diet diminished the increase in promoter-H3K23Pr and significantly reduced ECM gene expression and collagen deposition. Conversely, the BCAA-free diet abolished the downregulation of ETC I-V subunits, enhanced mitochondrial respiration, and curbed cardiac hypertrophy. Thus, lowering the intake of BCAA reduces histone propionylation, which moderates the effects of stress on the heart.

ORGANISM(S): Mus musculus

PROVIDER: GSE227228 | GEO | 2023/08/25

REPOSITORIES: GEO

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

Transcriptomics The effect of a BCCA-free diet on 2W pressure overload-induced cardiac gene expression [BCAA-free-2W-TAC-RNA-Seq]
2023-08-25 | GSE229128 | GEO
Genomics The effect of a BCCA-free diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC-ChIP-Seq]
2023-08-25 | GSE227227 | GEO
Genomics The effect of a BCCA-free, with 1% propionate, diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC with propionate-ChIP-Seq]
2023-08-25 | GSE227226 | GEO
Transcriptomics The effect of a BCCA-free diet, with 1% propionate, on 1W pressure overload-induced cardiac gene expression [BCAA-free w propionate-1W-TAC-RNA-Seq]
2023-08-25 | GSE227225 | GEO
Transcriptomics The effect of a BCCA-free diet on 1W pressure overload-induced cardiac gene expression
2023-08-25 | GSE227110 | GEO
Genomics The effect of a BCCA-free diet on 2W pressure overload-induced H3K23-propionyl [BCAA-free-2W-TAC-ChIP-Seq]
| PRJNA944184 | ENA
Genomics The effect of a BCCA-free diet on 2W pressure overload-induced cardiac gene expression [BCAA-free-2W-TAC-RNA-Seq]
| PRJNA953011 | ENA
Genomics The effect of a BCCA-free diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC-ChIP-Seq]
| PRJNA944183 | ENA
Genomics The effect of a BCCA-free, with 1% propionate, diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC with propionate-ChIP-Seq]
| PRJNA944182 | ENA
Genomics Lowering dietary BCAA reduces fibrosis, enhances mitochondrial respiration, and curbs cardiac hypertrophy, via regulating histone H3K23-propionylation
| PRJNA953006 | ENA