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Chronic hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch2]

ABSTRACT: Purpose: To identify the gene expression change under chronic hypoxia on HBE cells. Methods: bulk RNA-seq was performed on primary human bronchial epithelial cells (HBE) that were cultured on air-liquid interface (ALI) condition and treated under normoxia or hypoxia (1% O2) for 5days. Results: inflammatory cytokines, collagen degradation, and angiogenic genes were upregulated under chronic hypoxia.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227501 | GEO | 2023/08/22

REPOSITORIES: GEO

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Hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch1]

Project description:Purpose: To identify the gene expression change under hypoxia on HBE cells. Methods: bulk RNA-seq was performed on primary human bronchial epithelial cells (HBE) that were cultured on air-liquid interface (ALI) condition and treated under normoxia or hypoxia (1% O2) for 6hr, 24hr, and 5days. Results: hypoxia-related genes were significantly upregulated under hypoxia including EGLN3.

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