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Apolipoprotein E deficiency potentiates macrophage resistance to staphylococcus aureus osteomyelitis via regulating cholesterol metabolism

ABSTRACT: To explore how APOE functions in the mechanism of regulation of cholesterol metabolism during S. aureus osteomyelitis, we established S. aureus osteomyelitis models in WT mice and APOE knockout mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of bone marrow from mice mentioned above at day 7 after operation.

ORGANISM(S): Mus musculus

PROVIDER: GSE227521 | GEO | 2023/07/09

REPOSITORIES: GEO

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Biphasic effects of pleiotropic cytokine IL-27 during Staphylococcus aureus implant-associated osteomyelitis

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Apolipoprotein E deficiency potentiates macrophage against <i>Staphylococcus aureus</i> in mice with osteomyelitis via regulating cholesterol metabolism.

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