Transcriptomics

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The inhibitory receptor Siglec-G controls the severity of chronic lymphocytic leukemia


ABSTRACT: Chronic Lymphocytic Leukaemia (CLL) is the most common leukemia in adults in the Western world. B cell receptor (BCR) signalling is known to be crucial for the pathogenesis and maintenance of CLL cells develop from mature CD5+ B cells. BCR signalling is regulated by the inhibitory co-receptor Siglec-G and Siglec-G-deficient mice have an enlarged CD5+ B1a cell population. Here, we determine how Siglec-G expression influences the severity of CLL.

ORGANISM(S): Mus musculus

PROVIDER: GSE227678 | GEO | 2023/05/03

REPOSITORIES: GEO

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