Transcriptomics

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Gene expression profiling of 3T3 fibroblast cells cultured with degradable metallic materials


ABSTRACT: Metals have been used for coronary artery stent materials in order to prevent stenosis caused by atherosclerosis. Degradable metallic materials (DMMs) are considered to be useful to avoid in-stent restenosis and late thrombosis. A new DMM, Fe-35Mn alloy, was fabricated through powder metallurgy in order to satisfy the ideal criteria of cardiovascular stent made of DMM. Since in-stent restenosis is mediated by the extracellular matrix production, which is mostly regulated by fibroblasts, the gene expression profile of 3T3 fibroblasts in the presence of Fe-35Mn alloy was then investigated. The mechanism of cellular responses in the presence of DMM is then expected to be clearly described through the gene profiling experiment.

ORGANISM(S): Mus musculus

PROVIDER: GSE22794 | GEO | 2010/07/24

SECONDARY ACCESSION(S): PRJNA127817

REPOSITORIES: GEO

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