Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/MAPK pathway [RNA-seq]

ABSTRACT: To investigate the function of SETD2 in SMAD4-mutant colorectal cancer, we induced colorectal cancer in mice with intestinal epithelium-specific knockout of SMAD4 and SETD2 using AOM/DSS treatment.

ORGANISM(S): Mus musculus

PROVIDER: GSE228024 | GEO | 2023/11/21

REPOSITORIES: GEO