ScRNA-seq analysis of tumor-infiltrating CD45+ cells from sitagliptin-treated mice
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ABSTRACT:
ORGANISM(S): Mus musculus
PROVIDER: GSE228128 | GEO | 2024/02/21
REPOSITORIES: GEO
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Project description:Dendritic cell (DC)-mediated antigen presentation is essential for the priming and activation of tumor-specific T cells. However, few drugs that specifically manipulate DC functions are available. Here, we observed that DCs initiated a distinct transcriptional program during antigen presentation. We utilized a network-based approach to screen for DC-targeting therapeutics. Sitagliptin, an oral gliptin widely used for type 2 diabetes, was identified as a drug that targets DCs. In mouse models, sitagliptin inhibited tumor growth by enhancing DC-mediated antigen presentation, leading to better T cell activation.
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Project description:scRNA-seq analysis of tumor-infiltrating CD45+ cells from sitagliptin-treated mice
| PRJNA948366 | ENA
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