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Effect of Arid1a deletion on chromatin accessibility in antiviral effector CD8+ T cells. [ATAC-Seq]

ABSTRACT: To investigate the role of ARID1A in the regulation of effector CD8+ T cell responses, we crossed GzmB-Cre P14 Thy1.1 mice with Arid1a-fl/fl mice to generate Arid1a Het and KO mice. We then performed chromatin accessibility profiling analysis by ATAC-seq in WT, Het, and KO cells in vivo at d0, 48h in vitro activated, d3, d5, and d8 post-LCMV Armstrong infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE228171 | GEO | 2023/06/13

REPOSITORIES: GEO

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Effect of Arid1a deletion in antiviral effector CD8+ T cells. [RNA-seq]

Project description:To investigate the roll of ARID1A in the regulation of effector CD8+ T cell responses, we crossed GzmB-Cre P14 Thy1.1 mice with Arid1a-fl/fl mice to generate Arid1a Het and KO mice. We then performed gene expression profiling analysis of WT, Het, and KO cells in vivo at d3, d5, and d8 post-LCMV Armstrong infection.

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Effect of Arid1a deletion on chromatin accessibility in antiviral effector CD8+ T cells. [Cut & Run]

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Genome-wide maps of chromatin state in naïve CD4+ T cells, WT/EZH2-null TFH and TH1 cells

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Expression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells

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TGFb is involved in type 1 alveolar epithelial cell plasticity and extracellular matrix gene transcription

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Cullin 3 Mouse Brain TMT-based Proteomics Analysis

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2021-03-26 | PXD017040 | Pride

The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation

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