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Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure [fruit fly]

ABSTRACT: The diagnosis of Parkinsonism is based on motor symptoms that are caused by reduced dopaminergic output However, decades earlier, patients report non-motoric problems, including hyposmia It is not known if non-motor and motor defects are causally connected Here we used single-cell transcriptome sequencing (10x) of young and olf fly mutants (whole brain) and human patients (three regions: nucleus basalis of Meynert, nucleus accumbens and putamen). This atlas reveals early defects in cholinergic neurons that are recapitulaed across species

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE228843 | GEO | 2025/03/01

REPOSITORIES: GEO

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Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure [human]

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