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BMAL1 Modulates Senescence Programming via AP-1 (WT and Bmal1 KO RNA-seq)

ABSTRACT: Cellular senescence and circadian dysregulation are biological hallmarks of aging. Whether they are interdependent has not been thoroughly studied. We hypothesize that BMAL1, a pioneer transcription factor and master regulator of the molecular circadian clock, plays a role in the senescence program. In this study, we show that BMAL1 in is uniquely localized to genomic motifs associated with AP-1 in senescent cells and contributes to AP-1 transcriptional control of the senescence program.

ORGANISM(S): Mus musculus

PROVIDER: GSE229011 | GEO | 2023/08/22

REPOSITORIES: GEO

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