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P53-dependent transcription in hTERT-RPE1 cells

ABSTRACT: We investigated the genes that were most strongly activated by p53 in this immortalized human cell line following treatment with the MDM2 inhibitor nutlin-3a. To identify genes that were activated by p53, we comparatively analyzed parental cells and isogenic derivatives. Wild type, p53-knockout and cells harboring a heterozygous p53 A276P mutation were assessed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229160 | GEO | 2023/05/01

REPOSITORIES: GEO

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