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The enteric nervous system relays psychological stress to intestinal inflammation [ScRNASeqCD45seq]

ABSTRACT: The enteric nervous system relays psychological stress to intestinal inflammation [ScRNASeqCD45seq]

PROVIDER: PRJNA963161 | ENA |

REPOSITORIES: ENA

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The enteric nervous system relays psychological stress to intestinal inflammation

Project description:The enteric nervous system relays psychological stress to intestinal inflammation

| PRJNA963159 | ENA

The enteric nervous system relays psychological stress to intestinal inflammation [SnRNASeq_ENS]

Project description:Mental health profoundly impacts inflammatory responses in the body. This is particularly apparent in inflammatory bowel disease (IBD), where psychological stress is associated with disease flares. Here, we discover a critical role for the enteric nervous system (ENS) in mediating the aggravating effect of chronic stress on intestinal inflammation. We find that chronically elevated levels of glucocorticoids drive the generation of an inflammatory subset of enteric glia that promotes monocyte- and TNF-mediated colitis via CSF1. Additionally, glucocorticoids cause transcriptional immaturity in enteric neurons, acetylcholine deficiency, and dysmotility via TGFβ2. We verify the connection between the psychological state, intestinal inflammation, and dysmotility in two cohorts of human IBD patients. Together, these findings offer a mechanistic explanation for the impact of the brain on peripheral inflammation, define the ENS as a relay between psychological stress and gut inflammation, and suggest that stress management could serve as a valuable component of IBD care.

2023-05-25 | GSE229322 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [ScRNASeqCD45seq]

2023-05-25 | GSE229321 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]

2023-05-25 | GSE229320 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]

Project description:The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]

| PRJNA963162 | ENA

The enteric nervous system relays psychological stress to intestinal inflammation [SnRNASeq_ENS]

Project description:The enteric nervous system relays psychological stress to intestinal inflammation [SnRNASeq_ENS]

| PRJNA963163 | ENA

The enteric nervous system relays psychological stress to intestinal inflammation

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-25 | GSE229323 | GEO

RNA Expression Data from developing enteric nervous system (ENS) and bowel

Project description:The enteric nervous system (ENS) can control most essential gut functions owing to its organization into complete neural circuits consisting of a multitude of different neuronal subtypes. We used microarrays to identify transcription factor networks and signaling pathways involved in diversification and differentiation of enteric neurons during development of the enteric nervous system.

2017-12-05 | GSE100130 | GEO

Impact of 6-mercaptopurine on LPS treated primary cultures of enteric nervous system

Project description:Enteric nervous system is involved in the regulation of intestinal inflammation. We developped mouse primary cultures of enteric nervous system to study impact of LPS, as pro-inflammatory mediator, and of the pro-drug 6-mercaptopurine on enteric inflammatory pathways We used microarrays to detail the global programme of gene expression underlying enteric neuro-inflammation and identified classes of up-regulated genes during this process.

2021-04-02 | GSE171308 | GEO

Expression analysis of adult zebrafish enteric nervous system

Project description:The enteric nervous system (ENS) encompasses the intrinsic neuroglia networks of the gastrointestinal (GI) tract that are essential for digestive function and gut homeostasis. To investigate the ENS of zebrafish, we carried out bulk RNA sequencing on nuclei purified by FACS (fluorescent-activated cell sorting) representing both the Cherry+ (ENS) and Cherry- (non-ENS) muscularis externa cell populations of Tg(sox10:Cre;Cherry) zebrafish gut.

2020-09-14 | GSE145885 | GEO

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