Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Young Treg]

ABSTRACT: We then performed gene expression profiling analysis using data obtained from RNA-seq of young Altre-WT and Altre-KO Tregs.

ORGANISM(S): Mus musculus

PROVIDER: GSE229374 | GEO | 2023/05/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Altre-WT and Altre-KO]

Project description:To investigate the cooperative function Altre in the regulation of Tregs with aging, we established Altre CD4-CRE and Foxp3-CRE mice in which Altre has been knockout in CD4+ T cells or Tregs.

2023-05-19 | GSE227799 | GEO

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver

Project description:To find specific transcription factors (TFs) interact with Altre to regulate target gene expression by Cis- or Trans- action on chromatin.

2023-05-18 | PXD041040 | Pride

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Naive T cells, Th17 and Tregs]

Project description:We then performed gene expression profiling analysis using data obtained from RNA-seq of Naive T cells, Th17 and Tregs.

2023-05-19 | GSE227837 | GEO

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Young Treg]

Project description:A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Young Treg]

| PRJNA954301 | ENA

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-19 | GSE227838 | GEO

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver

Project description:A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver

| PRJNA947156 | ENA

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Naive T cells, Th17 and Tregs]

Project description:A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Naive T cells, Th17 and Tregs]

| PRJNA947159 | ENA

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing

Project description:Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson's disease gene) is a pacemaker regulating PDH activity in CD4+ regulatory T cells (Treg cells). DJ-1 binds to PDHE1-β (PDHB), inhibiting phosphorylation of PDHE1-α (PDHA), thus promoting PDH activity and oxidative phosphorylation (OXPHOS). Park7 (Dj-1) deletion impairs Treg survival starting in young mice and reduces Treg homeostatic proliferation and cellularity only in aged mice. This leads to increased severity in aged mice during the remission of experimental autoimmune encephalomyelitis (EAE). Dj-1 deletion also compromises differentiation of inducible Treg cells especially in aged mice, and the impairment occurs via regulation of PDHB. These findings provide unforeseen insight into the complicated regulatory machinery of the PDH complex. As Treg homeostasis is dysregulated in many complex diseases, the DJ-1-PDHB axis represents a potential target to maintain or re-establish Treg homeostasis.

2022-04-19 | GSE115269 | GEO

A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Altre-WT and Altre-KO]

Project description:A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Altre-WT and Altre-KO]

| PRJNA947081 | ENA

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

Project description:Foxp3(+) regulatory T cells (Treg cells) are required for immunological homeostasis. One notable distinction between conventional T cells (Tconv cells) and Treg cells is differences in the activity of phosphatidylinositol-3-OH kinase (PI(3)K); only Tconv cells downregulate PTEN, the main negative regulator of PI(3)K, upon activation. Here we found that control of PI(3)K in Treg cells was essential for lineage homeostasis and stability. Mice lacking Pten in Treg cells developed an autoimmune-lymphoproliferative disease characterized by excessive T helper type 1 (TH1) responses and B cell activation. Diminished control of PI(3)K activity in Treg cells led to reduced expression of the interleukin-2 (IL-2) receptor α subunit CD25, accumulation of Foxp3(+)CD25(-) cells and, ultimately, loss of expression of the transcription factor Foxp3 in these cells. Collectively, our data demonstrate that control of PI(3)K signaling by PTEN in Treg cells is critical for maintaining their homeostasis, function and stability.

| S-EPMC4297515 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data