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Microbial infection instigates tau-related pathology via activating neuroimmune cGAS-STING pathway

ABSTRACT: Microbial infection, the strong trigger to directly induce inflammation in brain, is long considered a risk factor of Alzheimer’s disease, but how these infections contribute to neurodegeneration remains underexplored. Using a modified herpesvirus potentially relevant to this disease, we found that its infection promotes tau-related pathology in part via activating neuroimmune cGAS-STING pathway in the tau mouse models. These represent a causal link of environmental infectious factors and neurodegenerative diseases.

ORGANISM(S): Mus musculus

PROVIDER: GSE229411 | GEO | 2024/04/11

REPOSITORIES: GEO

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