Transcriptomics

Dataset Information

0

Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway


ABSTRACT: Microbial infection, the strong trigger to directly induce inflammation in brain, is long considered a risk factor of Alzheimer's disease (AD), but how these infections contribute to neurodegeneration remains underexplored. To examine the effect of herpes simplex virus type 1 (HSV-1) infection on tauopathy in local hippocampus of P301S mice, we utilized a modified HSV-1 strain (mHSV-1) potentially relevant to AD, we found that its infection promotes tau-related pathology in part via activating neuroimmune cGAS-STING pathway in the tau mouse model. Specifically, Sting ablation causes the detectable improvement of neuronal dysfunction and loss in P301S mice, which is causally linked to lowered proinflammatory status in the brain. Administration of STING inhibitor H-151 alleviates neuroinflammation and tau-related pathology in P301S mice. These results jointly suggest that herpesviral infection, as the vital environmental risk factor, could induce tau-related pathology in AD pathogenesis partially via neuroinflammatory cGAS-STING pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE229411 | GEO | 2024/04/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2025-04-17 | GSE264504 | GEO
2024-08-22 | PXD053544 | Pride
2024-08-21 | GSE254103 | GEO
2024-08-21 | GSE254104 | GEO
2022-11-30 | GSE206368 | GEO
| PRJNA1102867 | ENA
| PRJNA954379 | ENA
2024-01-18 | GSE180672 | GEO
2025-04-14 | GSE294097 | GEO
2024-12-21 | PXD046808 | Pride