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Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE229419 | GEO | 2024/03/20

REPOSITORIES: GEO

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Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [lncRNA]

Project description:To detect total RNA in microglia derived from AD mice (5xFAD) brain we single cell sorted Cd11b+ and Cd45+ cells divided by Methoxy-X04 staining (Ab aggregates) positivity We performed differentially expression analysis of RNA-seq of wild-type microglia (Me-X04 neg), non-phagocytic AD microglia (Me-X04 neg), phagocytic AD microglia (Me-X04 positive)

2024-03-20 | GSE229418 | GEO

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [short RNA]

Project description:To detect miRNAs in microglia derived from AD mice (5xFAD) brain we single cell sorted Cd11b+ and Cd45+ cells divided by Methoxy-X04 staining (Ab aggregates) positivity We performed differentially expression analysis of RNA-seq of wild-type microglia (Me-X04 neg), non-phagocytic AD microglia (Me-X04 neg), phagocytic AD microglia (Me-X04 positive)

2024-03-20 | GSE229417 | GEO

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [BV-2 cells]

Project description:To detect miRNA targets in glioblastoma cell line (BV-2) we stimulate the cells with LPS 10ng/ml or vehicle and then transfect them with miRNA mimics or scrable control We performed differentially expression analysis of RNA-seq BV-2 cells vehicle or LPS stimulated overexpressing miRNA mimic or scramble mimic

2024-03-20 | GSE229416 | GEO

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Project description:Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

| PRJNA954390 | ENA

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [lncRNA]

Project description:Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [lncRNA]

| PRJNA954393 | ENA

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [short RNA]

Project description:Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [short RNA]

| PRJNA954394 | ENA

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [BV-2 cells]

Project description:Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [BV-2 cells]

| PRJNA954387 | ENA

Primate-specific Long Non-coding RNAs and MicroRNAs.

Project description:Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs.

| S-EPMC5487532 | biostudies-literature

Long non-coding RNAs expression profile in HepG2 cells reveals the potential role of long non-coding RNAs in the cholesterol metabolism.

Project description:BackgroundGreen tea has been shown to improve cholesterol metabolism in animal studies, but the molecular mechanisms underlying this function have not been fully understood. Long non-coding RNAs (lncRNAs) have recently emerged as a major class of regulatory molecules involved in a broad range of biological processes and complex diseases. Our aim was to identify important lncRNAs that might play an important role in contributing to the benefits of epigallocatechin-3-gallate (EGCG) on cholesterol metabolism.MethodsMicroarrays was used to reveal the lncRNA and mRNA profiles in green tea polyphenol(-)-epigallocatechin gallate in cultured human liver (HepG2) hepatocytes treated with EGCG and bioinformatic analyses of the predicted target genes were performed to identify lncRNA-mRNA targeting relationships. RNA interference was used to investigate the role of lncRNAs in cholesterol metabolism.ResultsThe expression levels of 15 genes related to cholesterol metabolism and 285 lncRNAs were changed by EGCG treatment. Bioinformatic analysis found five matched lncRNA-mRNA pairs for five differentially expressed lncRNAs and four differentially expressed mRNA. In particular, the lncRNA AT102202 and its potential targets mRNA-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) were identified. Using a real-time polymerase chain reaction technique, we confirmed that EGCG down-regulated mRNA expression level of the HMGCR and up-regulated expression of AT102202. After AT102202 knockdown in HepG2, we observed that the level of HMGCR expression was significantly increased relative to the scrambled small interfering RNA control (P < 0.05).ConclusionsOur results indicated that EGCG improved cholesterol metabolism and meanwhile changed the lncRNAs expression profile in HepG2 cells. LncRNAs may play an important role in the cholesterol metabolism.

| S-EPMC4837827 | biostudies-literature

Distinct Hippocampal Expression Profiles of Long Non-coding RNAs in an Alzheimer’s Disease Model

Project description:In the present study, we applied microarray technology to analyse the expression profiles of lncRNAs and messenger RNAs (mRNAs) in the hippocampus of rats in a validated AD model. Additionally, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to predict the biological roles and potential signalling pathways of these differentially expressed lncRNAs.

2019-03-29 | GSE129015 | GEO

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