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Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [short RNA]

ABSTRACT: Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [short RNA]

PROVIDER: PRJNA954394 | ENA |

REPOSITORIES: ENA

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Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Project description:Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

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Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [lncRNA]

Project description:Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [lncRNA]

| PRJNA954393 | ENA

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [BV-2 cells]

Project description:Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [BV-2 cells]

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Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [short RNA]

Project description:To detect miRNAs in microglia derived from AD mice (5xFAD) brain we single cell sorted Cd11b+ and Cd45+ cells divided by Methoxy-X04 staining (Ab aggregates) positivity We performed differentially expression analysis of RNA-seq of wild-type microglia (Me-X04 neg), non-phagocytic AD microglia (Me-X04 neg), phagocytic AD microglia (Me-X04 positive)

2024-03-20 | GSE229417 | GEO

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [lncRNA]

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Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-20 | GSE229419 | GEO

Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs [BV-2 cells]

Project description:To detect miRNA targets in glioblastoma cell line (BV-2) we stimulate the cells with LPS 10ng/ml or vehicle and then transfect them with miRNA mimics or scrable control We performed differentially expression analysis of RNA-seq BV-2 cells vehicle or LPS stimulated overexpressing miRNA mimic or scramble mimic

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Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease

Project description:Age-associated microglial dysfunction contributes to the accumulation of amyloid-b (Ab) plaques in Alzheimer’s disease. Although several studies have shown age-related declines in the phagocytic capacity of myeloid cells, relatively few have examined phagocytosis of normally aged microglia. Furthermore, much of the existing data on aging microglial function have been generated in accelerated genetic models of Alzheimer’s disease. Here we found that naturally aged microglia phagocytosed less Ab over time. To gain a better understanding of such dysfunction, we assessed differences in gene expression between young and old microglia that either did or did not phagocytose Ab. Young microglia had both phagocytic and neuronal maintenance signatures indicative of normal microglial responses, whereas, old microglia, regardless of phagocytic status, exhibit signs of broad dysfunction reflective of underlying neurologic disease states. We also found downregulation of many phagocytic receptors on old microglia, including TREM2, an Ab phagocytic receptor. TREM2 protein expression was diminished in old microglia and loss of TREM2+ microglia was correlated with impaired Ab uptake, suggesting a mechanism for phagocytic dysfunction in old microglia. Combined, our work reveals that normally aged microglia have broad changes in gene expression, including defects in Ab phagocytosis that likely underlies the progression to neurologic disease.

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Adherent Intestinal Cells from Atlantic Salmon Show Phagocytic Ability and Express Macrophage Markers

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Transcriptome profiling of phagocytic or non-phagocytic microglia from Ifngr1 cKO mice.

Project description:Transcriptome profiling of phagocytic or non-phagocytic microglia from Ifngr1 cKO mice.

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