Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [RNA-seq]

ABSTRACT: To investigate the function of long noncoding RNA lncMGC in WT and lncMGC KO mouse kidney mesangial cells treated with TGF-ß. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 types of kidney messangial cell samples: wild type (WT) or lncMGC knockout (lncMGC_KO) mouse, each treated with either SD or TGF-ß, namely WT_SD, WT_TGF, KO_SD and KO_TGF.

ORGANISM(S): Mus musculus

PROVIDER: GSE229688 | GEO | 2023/06/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [ATAC-seq]

Project description:To investigate the function of long noncoding RNA lncMGC in WT and lncMGC KO mouse kidney mesangial cells treated with TGF-ß. Assay for Transposase-Accessible Chromatin (ATAC) sequencing on 4 types of kidney messangial cell samples: isolated from wild type (WT) or lncMGC knockout (lncMGC_KO) mouses, each treated with either SD or TGF-ß, namely WT_SD, WT_TGF, KO_SD and KO_TGF.

2023-06-21 | GSE229686 | GEO

Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [ChIP-seq]

Project description:To investigate the function of long noncoding RNA lncMGC in WT and lncMGC KO mouse kidney mesangial cells treated with TGF-ß. Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for histone modication mark H3K27ac on 4 types of kidney messangial cell samples: isolated from wild type (WT) or lncMGC knockout (lncMGC_KO) mouses, each treated with either SD or TGF-ß, namely WT_SD, WT_TGF, KO_SD and KO_TGF.

2023-06-21 | GSE229687 | GEO

Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment

Project description:Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment

| PRJNA955290 | ENA

Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [ChIP-seq]

Project description:Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [ChIP-seq]

| PRJNA955293 | ENA

Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [ATAC-seq]

Project description:Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [ATAC-seq]

| PRJNA955291 | ENA

Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [RNA-seq]

Project description:Effect of lncMGC on gene expression of kidney mesangial cells under SD or TGF-ß treatment [RNA-seq]

| PRJNA955292 | ENA

MDA-MB-468 Smad4 positive/negative clones treated with TGF-ß

Project description:By performing oligonucleotide microarray analysis the role of Smad4 in response to TGF-ß was evaluated in established MDA-MB-468 Smad4 negative and positive clones that were treated with TGF-ß for different time points. Keywords: time-course

2006-04-25 | GSE2567 | GEO

Stabilization of ß-catenin during murine Kidney Development

Project description:We define a pathogenic role for a ß-catenin-activated genetic pathway in murine renal dysplasia. Cre-mediated stabilization of ß-catenin in the ureteric cell lineage prior to the onset of kidney development increased ß-catenin levels and caused renal aplasia or severe hypodysplasia. A genome-wide analysis of mRNA expression in dysplastic tissue identified down-regulation of genes required for ureteric branching and up regulation of Tgfß2 and Dkk1. Hoxb7-Cre:EGFP mice ( Zhao, et al. (2004) Dev Biol 276:403-415) were crossed with mice containing loxP sites flanking exon 3 of the ß-catenin allele (ß-catdelta3/delta3) (Harada,et al. (2002) Cancer Res 62:1971-1977) to generate ß-catenin gain-of-function mutant mice specific to the uteric bud, termed ß-catGOF-UB .Eighteen ß-catGOF-UB mutant kidneys and 9 WT kidneys were micro-dissected at E12.5. Mutant kidneys were divided into three random pools (n=3) consisting of 6 kidneys each and mRNA expression assessed by microarray.

2011-03-28 | E-GEOD-20325 | biostudies-arrayexpress

TGF-ß treatment of human melanoma cell lines

Project description:To analyse whether the activation of TGF-ß signalling (recombinant hTGF-ß, 5 ng/mL; PeproTech) is able to invoke a full phenotype- switch, we performed RNA sequencing of melanoma cultures from two independent melanoma cell lines at two different time point after TGF-β1 (5 ng/ml, preprotech).

2020-04-17 | GSE148767 | GEO

Gene expression profiles of human mesangial cell line treated with and without ANGPT2

Project description:Glomerular diseases are the leading cause of chronic kidney diseases with pathomechanisms largely unclear. It is known that ANGPT2 regulates endothelial cell homeostasis and function via TEK/TIE2 and its deregulation causes endothelial damage. We found that ANGPT2 is upregulated in glomerular diseases and wondered whether it has any effect on glomerular podocytes and mesangial cells given that they have no or low TEK expression. We treated podocytes and mesangial cells in culture with ANGPT2 and found no overt cellular changes. RNA-seq analysis showed that gene expression was altered in both podocytes and mesangial cells and that the regulated genes in the two cell types were fundamentally different. GO and KEGG analyses showed that the two groups of regulated genes were enriched in distinct processes and pathways. These results suggest that ANGPT2 exerts effects on both podocytes and mesangial cells and that increased ANGPT2 may be involved in glomerular injury by affecting podocytes and mesangial cells in addition to endothelial cells.

2022-01-10 | GSE185293 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data