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Effect of early-life plane of nutrition on the transcriptional profile of the anterior pituitary gland in heifer calves

ABSTRACT: The aim of this study was to examine changes in the transcriptional profile of the anterior pituitary gland of heifer calves offered varying planes of nutrition during the early life period. From approximately 3 weeks of age (19 ± 5 days of age) Angus X Holstein-Friesian heifer calves were offered either a high (HP, n=13) or moderate (MP, n=15) plane of nutrition to achieve target growth rates of 1.2 kg/d and 0.5 kg/d, respectively. After 18 weeks of differential feeding all calves were euthanized and anterior pituitary tissue samples harvested from each calf. RNA was extracted and subsequently subjected to RNAseq analysis. A total of 195 genes were identified as significantly differentially expressed between calves on the High plane of nutrition and those on the Moderate plane of nutrition. Biological pathway analysis revealed an enrichement from these genes for processes and pathways related to growth and reproductive system development.

ORGANISM(S): Bos taurus

PROVIDER: GSE230543 | GEO | 2024/07/04

REPOSITORIES: GEO

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