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Proteomic profiling of anterior pituitary of heifer calves offered either a high or moderate plane of nutrition in early life

ABSTRACT: Enhanced nutrition during the early calfhood period has been shown to hasten the onset of puberty in heifer calves. The hypothalamic-pituitary-ovarian biochemical signalling axis regulates reproductive development in heifers, with the dynamics of gonadotropin pulsatility within the anterior pituitary gland, in particular, central to final sexual maturity. However, the precise molecular mechanisms regulating the influence of metabolic status on this signalling axis in heifer calves is yet to be fully elucidated. The objective of this study was to determine the effect of an enhanced plane of nutrition during early life, up to 21 weeks of age, on the anterior pituitary gland proteome of heifer calves. Heifer calves were offered either a high or moderate plane of nutrition. Pathway analysis of differentially abundant proteins highlighted an effect on both growth hormone and GnRH signalling pathways, as well as an effect towards reproductive system development and function

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Brain

SUBMITTER: Tara Carthy

LAB HEAD: David Kenny

PROVIDER: PXD042011 | Pride | 2024-07-04

REPOSITORIES: Pride

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			Action	DRS
	20181124_003_S187312_3620_High.raw	Raw
	20181124_004_S187304_1050_High.raw	Raw
	20181124_005_S187322_2537_Low.raw	Raw
	20181124_006_S187301_986_High.raw	Raw
	20181124_008_S187308_2570_High.raw	Raw

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