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Chromatin contacts within a fountain-like structure

ABSTRACT: Hundreds of DNA replication forks functioning simultaneously are essential for timely DNA duplication, but the organization of replication forks are poorly understood in mammalian cells. Here, we developed a replication-enriched in situ HiC (Repli-HiC) method to capture chromatin contacts located adjacent to replication forks and found two types of fountain-like chromatin contacts at thousands of loci. Interactions within fountain-spanning regions are confirmed by q3C-seq analysis of different stages of S phase cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE230613 | GEO | 2024/03/04

REPOSITORIES: GEO

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