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DNA accessibility profiling at the single nucleus level of post mortem white matter brain tissue of patients with progressive multiple sclerosis and non-neurological disease controls

ABSTRACT: Different lesion types were microdissected out from snap-frozen white matter. Brain nuclei were fluorescence-activated nuclear sorted and treated with Transposase Tn5. Gel beads-in-emulsion was generated, barcoded followed by library construction and sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE231584 | GEO | 2024/06/21

REPOSITORIES: GEO

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Gene expression profiling at single nucleus level of microdissected white matter tissue samples of patients with progressive multiple sclerosis and non-neurological disease controls

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