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Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model [Bulk RNA-seq]

ABSTRACT: To study the effects of the loss of Sox7 function on gene expression of the endothelium in vivo during development. We generated a endothelial specific ko using a Sox7fl/fl Cdh5 creERT2 inducible system.

ORGANISM(S): Mus musculus

PROVIDER: GSE231635 | GEO | 2023/07/25

REPOSITORIES: GEO

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Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model [scRNA-seq]

Project description:To study the effects of the loss of Sox7 function on gene expression of the endothelium in vivo during development. We generated a endothelial specific ko using a Sox7fl/fl Cdh5 creERT2 inducible system.

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Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model

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Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model

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Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model [scRNA-seq]

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Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model [Bulk RNA-seq]

Project description:Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model [Bulk RNA-seq]

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m6A-sequencing of Mettl14-conditional knock-out retinas and matched control.

Project description:Post-transcriptional m6A methylation on mRNA plays a key role in neural development. Here, we specifically depleted Mettl14 (a key component of m6A complex) in retina progenitor cells by crossing Mettl14 fl/fl mice with the Chx10-Egfp/Cre mouse line and investigated Mettl14 depletion-induced m6A alteration in developing retinas using m6A-seq.

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