Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression analysis of F9 cells double knock-down for Sox7 and Sox17


ABSTRACT: Analysis of the expression of F9 cells after knockdown of Sox7 and Sox17 during their primitive endoderm differnetiation induction with retinoic acid. Results provide information on the endodermal gene expression program regulated by Sox7 and Sox17. Sox7 Sox17 double KD vs. control in F9 cells

ORGANISM(S): Mus musculus

SUBMITTER: Irene Aksoy 

PROVIDER: E-GEOD-43232 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


How regulatory information is encoded in the genome is poorly understood and poses a challenge when studying biological processes. We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification. We show that Sox17 partners with Oct4 and binds to a unique 'compressed' Sox/Oct motif that earmarks endodermal genes. This is in contrast to the pluripotent state where Oct4 selectively partners with Sox  ...[more]

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