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NRF1 promotes primordial germ cell development, proliferation, and survival

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE231663 | GEO | 2023/08/05

REPOSITORIES: GEO

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NRF1 promotes primordial germ cell development, proliferation and survival.

Project description:Primordial germ cells (PGCs) are the germline precursors that give rise to oocytes and sperm, ensuring the continuation of life. While the PGC specification is extensively studied, it remains elusive how the PGC population is sustained and expanded after they migrate to embryonic gonads before birth. This study demonstrates that NRF1, a known regulator for mitochondrial metabolism, plays critical roles in post-migrating PGC development. We show that NRF1 protein level gradually increases in post-migrating PGCs during embryonic development. Conditional Nrf1 knockout from embryonic germ cells leads to impaired PGC proliferation and survival. In addition, NRF1 may also actively drive PGC derivation from pluripotent stem cells. Using whole genome transcriptome profiling and ChIP-seq analyses, we further reveal that NRF1 directly regulates key signalling molecules in PGC formation, transcription factors in proliferation and cell cycle and enzymes in mitochondrial metabolism. Overall, our findings highlight an essential requirement of NRF1 in regulating a broad transcriptional network to support post-migrating PGC development both in vitro and in vivo.

| S-EPMC10771101 | biostudies-literature

NRF1 promotes primordial germ cell development, proliferation, and survival [RNA-seq]

Project description:To investigate the role of NRF1 in regulating primordial germ cell development, We established conditional knockout mice of Nrf1 in primordial germ cell to observe the effect of Nrf1 knockout on the development of primordial germ cell. At the same time, we utilized a pluripotent stem cell differentiation system in vitro to obtain PGCL cells for chip_ Seq, analyze which genes Nrf1 directly binds to. Meanwhile, we established a pluripotent stem cell line induced by Nrf1 overexpression and performed RNA_seq analysis on PGCL cells overexpressing Nrf1 obtained in vitro

2023-08-05 | GSE231662 | GEO

NRF1 promotes primordial germ cell development, proliferation and survival [ChIP-seq]

2023-08-05 | GSE231661 | GEO

NRF1 promotes primordial germ cell development, proliferation, and survival

Project description:NRF1 promotes primordial germ cell development, proliferation, and survival

| PRJNA967266 | ENA

NRF1 promotes primordial germ cell development, proliferation, and survival [RNA-seq]

Project description:NRF1 promotes primordial germ cell development, proliferation, and survival [RNA-seq]

| PRJNA967271 | ENA

NRF1 promotes primordial germ cell development, proliferation and survival [ChIP-seq]

Project description:NRF1 promotes primordial germ cell development, proliferation and survival [ChIP-seq]

| PRJNA967267 | ENA

Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-16 | GSE151446 | GEO

Genome-wide methylation profiles in primary intracranial germ cell tumors indicate primordial germ cell origin of germinoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-01 | E-GEOD-70787 | biostudies-arrayexpress

An RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-31 | E-GEOD-39547 | biostudies-arrayexpress

AKT Inhibition Promotes Non-autonomous Cancer Cell Survival

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-12-09 | E-GEOD-71901 | biostudies-arrayexpress

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