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Gene expression profile at single cell level of non-malignant cells in KRAS syngeneic mouse tumor models

ABSTRACT: STK11/LKB1 mutation is a primary driver for immunotherapy resistance. We employed KRAS/LKB1 syngeneic mouse models by injecting tumor cells with Kras mutation, Kras/Stk11 mutation and MCT4 knockout. We used single-cell RNA-seq to analyze the impact of LKB1 deficiency on the immune microenvironment.

ORGANISM(S): Mus musculus

PROVIDER: GSE231742 | GEO | 2023/05/10

REPOSITORIES: GEO

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Genome-wide analysis of Schwann cell gene expression in LKB1-SCKO mutant mice prior to occurrence of axon degeneration

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