Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MCPIP1 functions as a safeguard of early embryonic development

ABSTRACT: Expression of zc3h12a encoding Mcpip1 is tightly controlled within first cell divisions of zebrafish. Overexpression of Mcpip1 leads to the profound transcriptomic changes in the developing embryos and impairs early embryonic development of zebrafish.

ORGANISM(S): Danio rerio

PROVIDER: GSE232220 | GEO | 2023/07/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

MCPIP1 functions as a safeguard of early embryonic development

Project description:MCPIP1 functions as a safeguard of early embryonic development

| PRJNA971233 | ENA

Regulation of miRNA biogenesis by MCPIP1

Project description:Effect of MCPIP1 knockdown on miRNA expression profile. HepG2 cells were transfected with control siRNA or siRNA against MCPIP1, and subjected to miRNA microarray analysis.

2011-11-05 | E-GEOD-31091 | biostudies-arrayexpress

Distinct roles of keratinocyte- and myeloid- MCPIP1 in maintaining skin homeostasis

Project description:The morphology of the skin changes upon depletion of MCPIP1 in cells of myeloid origin as well as in keratinocytes. The thicknesses of epidermal and hypodermal layers are significantly increased in mice with loss of epidermal MCPIP1, whereas loss of myeloid MCPIP1 exerts completely opposite effect. Both types of mice show contrary response to the stimulation with 12-O-tetradecanoylphorbol-13-acetate. Skin morphology and inflammatory phenotype of keratinocyte- and myeloid- double MCPIP1 knockout mice is similar to that of the single keratinocyte knockout of MCPIP1. In all, myeloid and epidermal MCPIP1 play significant but distinct roles in the modulation of skin-related processes.

2024-07-09 | GSE253656 | GEO

Regulation of miRNA biogenesis by MCPIP1

Project description:Effect of MCPIP1 knockdown on miRNA expression profile.

2011-11-05 | GSE31091 | GEO

MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth

Project description:Depletion of Mcpip1 in the cells of myeloid origin modifies the sensitivity to the cutaneous chemical carcinogenesis. It attenuates epidermal proliferation and increases the susceptibility to the formation of melanocytic nevi. Thus, myeloid Mcpip1 is an important modulator in the course of skin carcinogenesis.

2023-12-08 | GSE242128 | GEO

Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism

Project description:Obesity is considered a serious chronic disease, which is associated with increased risk of developing cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes. Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1), also called Regnase-1, is an RNase that decreases stability of transcripts coding for inflammation-related proteins. In addition, MCPIP1 plays an important role in the regulation of adipogenesis in vitro by reducing the expression of key transcription factors, including C/EBPβ and PPARγ, during adipocyte differentiation. Here we present RNA-Seq and proteomic analysis of 3T3-L1 adipocytes overexpressing wild-type MCPIP1 (WTMCPIP1) and mutant MCPIP1 (D141NMCPIP1) at day 2 and 4 of differentiation, respectively. RNA-Seq analysis followed by confirmatory Q-RT-PCR revealed that elevated MCPIP1 levels in 3T3-L1 adipocytes upregulated transcripts encoding proteins involved in signal transmission and cellular remodeling and downregulated transcripts of factors involved in metabolism. These data are consistent with our LC-MS/MS analysis, which showed that MCPIP1 expressing adipocytes exhibit upregulation of proteins involved in cellular organization and movement and decreased levels of proteins involved in lipid and carbohydrate metabolism. Moreover, MCPIP1 adipocytes are characterized by decreased Glut4 levels and impaired glucose uptake. Overall, our ﬁndings demonstrate that MCPIP1 is an important regulator of adipogenesis and adipocyte metabolism.

2020-01-07 | PXD010148 | Pride

Small RNAseq of MV3 melanoma cells overexpressing MCPIP1 protein

Project description:Sequencing of small RNAs in RNA samples from control cells, cells overexpressing wild-type and mutated form of MCPIP1 ribonuclease

2021-03-01 | GSE164227 | GEO

MCPIP1 role in adipogenesis and adipocytes metabolism

Project description:Integrative genomics reveals MCPIP1 role in adipogenesis and adipocytes metabolism

| PRJEB27195 | ENA

Small RNAseq of MV3 melanoma cells overexpressing MCPIP1 protein

Project description:Small RNAseq of MV3 melanoma cells overexpressing MCPIP1 protein

| PRJNA689586 | ENA

Project description:Ectopic overexpression of MCPIP1 impairs adipogenesis by modulating microRNAs.

| PRJEB20090 | ENA