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Expression data from K562 hemin differentiation

ABSTRACT: We used microarrays to detail the global programme of gene expression underlying erythroid differentiation using K562 cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232511 | GEO | 2023/08/31

REPOSITORIES: GEO

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Expression data from K562 hemin differentiation

Project description:Expression data from K562 hemin differentiation

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Expression data from PML4 overexpressing and control K562 cells

Project description:PML functions as a platform for the interaction of transcription factors and coactivators. Role of PML in erythroid clone formation has been reported but the detail mechanism is unclear. We used microarrays to identify downstream-regulated genes of PML4. We transfected K562 cells with retrovirus overexpressing PML4 and control vector pMSCV for RNA extraction and hybridization on Affymetrix microarrays.

2013-07-13 | E-GEOD-48842 | biostudies-arrayexpress

ARID3a is Required for Erythrocyte Lineage Differentiation of Hemin Stimulated Human K562 Cells

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ChIP-chip from 48h hemin induced K562 cells with GATA-1, EKLF, and NF-E2 antibodies

Project description:The transcription factor GATA-1, EKLF and NF-E2 promotes erythroid differentition by regulating their target genes, however, the intricate interplays between these key TFs and microRNA genes are largely unknown. Chromatin immunoprecipitation (ChIP) of GATA-1, EKLF and NF-E2 together with microRNA genomic promoter profiling by ChIP-on-chip analysis demonstrated that GATA-1, EKLF and NF-E2 collaborately regulate a series of microRNA genes. Comparison of microRNA promoter arrays of GATA-1 VS EKLF VS NF-E2 in K562 cells suffering with hemin induced erythroid differentiation

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Project description:K562 erythroleukemia cells after erythroid differentiation caused by incubation in the presence of hemin

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Expression data from PML4 overexpressing and control K562 cells

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Gene expression changes induced in K562 cells by the homeobox gene DLX4 and by treatment with Activin A and phorbol 12-myristate 13-acetate

Project description:Homeobox genes encode transcription factors that control patterning of virtually all organ systems including the hematopoietic system. However, the role of homeobox genes in controlling development of the erythroid and megakaryocytic lineages is poorly understood. In this study, we investigated the role of the homeobox gene DLX4 in erythroid and megakaryocytic differentiation using the bipotent cell line K562 as a model. We compared the global gene expression profile of K562 cells that stably overexpressed DLX4 with that of vector-control K562 cells. As positive controls, global gene expression profiles were evaluated in vector-control K562 cells that were stimulated with Activin A (ActA) to induce erythroid differentiation and in vector-control K562 cells that were stimulated with phorbol 12-myristate 13-acetate (PMA) to induce megakaryocytic differentiation. Our study provides insights into the role of homeobox genes in controlling differentiation of the erythroid and megakaryocytic lineages. Three groups of samples were included: DLX4 vs Empty vector; Activin A vs None; PMA vs DMSO

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Voltage-Gated K+ Channel, Kv3.3 Is Involved in Hemin-Induced K562 Differentiation.

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MicroRNAs in neuronal differentiation

Project description:We used microarrays to detail the global programme of miRNA expression during neuronal differentiation

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Analysis of gene expression changes in K562 erythroleukemia cells after erythroid differentiation caused by incubation in the presence hemin [RNA-Seq]

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2023-09-11 | GSE232390 | GEO

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