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Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs (RNA-Seq)

ABSTRACT: To detect the mechanism underlying osteogenic commitment and proliferation rate change of HDPCs driven by MDL-800, we performed gene expression profiling analysis for HDPCs with DMSO or MDL-800 pre-treatment under normal or osteogenic differentiation conditions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232535 | GEO | 2024/05/14

REPOSITORIES: GEO

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Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs (ChIP-Seq)

Project description:To detect the mechanism underlying osteogenic commitment and proliferation rate change of HDPCs driven by MDL-800, we performed ChIP-seq analysis to detect the recruitment of genes on H3K9ac and H3K56ac in MDL-800 pre-treated HDPCs.

2024-05-14 | GSE232534 | GEO

Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs

Project description:This SuperSeries is composed of the SubSeries listed below.

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Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs

Project description:Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs

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Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs (RNA-Seq)

Project description:Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs (RNA-Seq)

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Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs (ChIP-Seq)

Project description:Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs (ChIP-Seq)

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The SIRT6 Activator MDL-800 Extends Lifespan and Health-span of Mice

Project description:The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 6 (SIRT6), an NAD+-dependent deacetylase, improves metabolism and confers protection against physiological and cognitive disturbances in old age. Here we show that MDL-800 is a specific SIRT6 activator that has health and lifespan benefits in adult mice fed a standard diet. We found extension in lifespan, delayed onset of age-related metabolic diseases, and improved general health in mice fed a standard diet after MDL-800 supplementation. Treatment with MDL-800 induced synthesis of anti-oxidation related proteins, and this rejuvenated HSCs and ISCs in aged mice. Inhibition of pro-inflammatory gene expression in both liver and muscle of MDL-800-treated animals was noted. MDL-800 lowered the level of NF-kB pathway and improved fatty acid metabolism in liver. Combined with our previous work, the current study further supports the beneficial effects of MDL-800 on health across the lifespan in mice.

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Gene expression profile of human dental follicle cells (hDFCs) induced by conditioned medium derived from human dental pulp cells (hDPCs-CM)

Project description:The purpose of this study was to examine the effects of hDPCs-CM on osteogenic differentiation of hDFCs and to compare gene expression in hDFCs in the presence or absence of hDPCs-CM Total RNAs were isolated from hDFCs in osteogenic medium for 7 days with or without hDPCs-CM.

2014-09-30 | E-GEOD-61848 | biostudies-arrayexpress

The SIRT6 Activator MDL-800 Extends Lifespan and Health-span of Mice

Project description:The SIRT6 Activator MDL-800 Extends Lifespan and Health-span of Mice

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Gene expression profile of human dental follicle cells (hDFCs) induced by conditioned medium derived from human dental pulp cells (hDPCs-CM)

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Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.

Project description:SIRT6 belongs to the family of histone deacetylases (class III), but it also has mono-ADP-ribosyltransferase activity. SIRT6 is a nuclear sirtuin that has been associated with aging, cellular protection, and sugar metabolism. Despite these important roles for SIRT6, thus far, there are only a few weak SIRT6 inhibitors available, and no structure-activity relationship (SAR) studies have been published. This is the first study concerning peptides and pseudopeptides as SIRT6 deacetylation inhibitors and the first SAR data concerning SIRT6. We also investigated the molecular interactions using a homology model. We report three compounds exhibiting 62-91% SIRT6 inhibition at 200 ?M concentration. These compounds can serve as starting points for systematic SAR studies and SIRT6 inhibitor design.

| S-EPMC4025866 | biostudies-literature

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