Ontology highlight
ABSTRACT:
SUBMITTER: Kokkonen P
PROVIDER: S-EPMC4025866 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20121023 12
SIRT6 belongs to the family of histone deacetylases (class III), but it also has mono-ADP-ribosyltransferase activity. SIRT6 is a nuclear sirtuin that has been associated with aging, cellular protection, and sugar metabolism. Despite these important roles for SIRT6, thus far, there are only a few weak SIRT6 inhibitors available, and no structure-activity relationship (SAR) studies have been published. This is the first study concerning peptides and pseudopeptides as SIRT6 deacetylation inhibitor ...[more]