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Canabidiol (CBD) modulates the effect of ethanol on the fibroblast cells transcriptome in vitro

ABSTRACT: Considering reports about positive role of Cannabidiol (CBD) in alcohol abuse disorders, in this study we used cellular model of human fibroblasts to analyse the effect of CBD on ethanol-treated cells. We assumed, that CBD will (to some extent), prevent adverse transcriptional changes driven by alcohol administration and this effect will be detectable on the transcriptome level. As a by-product of this analysis, ethanol and CBD alone stimulated transcriptome changes were also described. We moreover considered that CBD effects are dose and time-dependent. As a model for these analyses we selected human fibroblast cell line as a most abundant cell type in human body that express e.g. both cannabinoid receptors (CB1 and CB2) and is able to metabolize ethanol trough alcohol dehydrogenase activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232624 | GEO | 2023/08/01

REPOSITORIES: GEO

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