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5' gene expression (GEX) single-cell RNA sequencing of four (4) Hodgkin Lymphoma patient tumor biopsies

ABSTRACT: Hodgkin lymphoma tumors are characterized by profound infiltration of immune cells. We used scRNA-seq to analyze the cellular composition of the tumor microenvironment in Hodgkin lymphoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232761 | GEO | 2024/04/15

REPOSITORIES: GEO

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5' gene expression (GEX) single-cell RNA sequencing of four (4) Hodgkin Lymphoma patient tumor biopsies

Project description:5' gene expression (GEX) single-cell RNA sequencing of four (4) Hodgkin Lymphoma patient tumor biopsies

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Project description:Hodgkin lymphoma is derived from germinal center / post-germinal center B cells. To determine differentially expressed genes between Hodgkin Reed Sternberg cells and their presumed cell of origin we investigated the expression profiles of 5 commonly used Hodgkin lymphoma cell lines as compared to reactive germinal centers.

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Classical Hodgkin lymphoma shows epigenetic features of an abortive plasma cellular differentiation: expression of Hodgkin vs. B-cell lines

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