Transcriptomics

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Effect of Mineralocorticoid Receptor deletion on glucocorticoid signalling in the macropahge


ABSTRACT: Inappropriate excess of the steroid hormone aldosterone, which is a mineralocorticoid receptor (MR) agonist, is associated with increased inflammation and risk of cardiovascular disease. MR antagonists are cardioprotective and antiinflammatory in vivo, and evidence suggests that they mediate these effects in part by aldosterone- independent mechanisms. We used affymetrix to characterize the effect of Mineralocorticoid Receptor deletion on macrophage transcriptional profile, and identify its requirement in normal glucocorticoid signalling.

ORGANISM(S): Mus musculus

PROVIDER: GSE23308 | GEO | 2010/07/30

SECONDARY ACCESSION(S): PRJNA131199

REPOSITORIES: GEO

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