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An organ-specific angiogenic control mechanism for endothelial tailoring

ABSTRACT: To address the role of endothelial Wnt/β-catenin signaling in CNS angiogenesis, we compared the bulk transcriptomes of WT and Wnt/β-catenin signaling-deficient PHBC endothelial cells, prior to CNS vascular invasion. To this end, we used three approaches to abrogate endothelial Wnt/β-catenin signaling: Morpholino-mediated knock-down of gpr124, reck or wnt7aa. We find that the expression of mmp25b is decreased in PHBC endothelial cells of all Wnt/β-catenin signaling deficient conditions as compared to the WT controls.

ORGANISM(S): Danio rerio

PROVIDER: GSE233488 | GEO | 2024/02/07

REPOSITORIES: GEO

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GPR124 regulates murine CNS angiogenesis and blood-brain barrier formation by an intracellular domain-independent mechanism

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