Transcriptomics

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Effect of overexpression of ESRP1 on gene expression of SGC7901 gastric cancer cells


ABSTRACT: RNA-binding proteins and their mediated alternative splicing play important roles in tumor cell invasion and migration. Here, we report that ESRP1 is a key regulator of gastric cancer cell metastasis. Overexpression of ESRP1 inhibits the invasion and migration of gastric cancer cells, in vivo and in vitro. Furthermore, we found that ESRP1 causes a wide range of alternative splicing events, and ESRP1-mediated CLSTN1 exon skipping may be a key mechanism for its inhibition of gastric cancer cell invasion and metastasis. Taken together, our data provide a molecular framework for the role of ESRP1 in gastric cancer development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE233685 | GEO | 2023/12/27

REPOSITORIES: GEO

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