Transcriptomics

Dataset Information

0

Development of potent antibody drug conjugates against ICAM1+ cancer cells in preclinical models of cholangiocarcinoma


ABSTRACT: We observed an interesting contradictory phenomenon that ICAM1-Dxd showed a very weak cytotoxicity on CCA cell lines in vitro, whereas it mediates more potent tumor attenuation than ICAM1-MMAE in vivo, suggesting the potency of ICAM1-Dxd may arise from its multifaceted biological activities instead of merely cytotoxicity. To elucidate its underlying biomechanism, we performed a transcriptomic RNA sequencing (RNA-seq) to profile the signaling pathways and key genes affected by ICAM1-Dxd treatment in PDX tumor tissues.

ORGANISM(S): Homo sapiens

PROVIDER: GSE233818 | GEO | 2023/09/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA978044 | ENA
| S-EPMC10505223 | biostudies-literature
2022-09-28 | GSE212232 | GEO
| S-EPMC11321650 | biostudies-literature
2024-06-28 | GSE254335 | GEO
2017-09-16 | GSE103909 | GEO
2024-06-22 | PXD048188 | Pride
2022-06-01 | GSE162845 | GEO
| PRJNA1069759 | ENA
2024-11-11 | GSE269783 | GEO