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RNA-seq of Recombinant Mouse Cold-inducible RNA-binding protein(rmCIRP)-treated Naïve CD4+ T cells

ABSTRACT: Cold-inducible RNA-binding protein (CIRP) is a ubiquitous intracellular RNA chaperon, which serves as a damage-associated molecular pattern (DAMP) when released outside the cells upon stimulation by inflammation and infection. It has been shown that CIRP promotes splenic CD4+ and CD8+ T-cell activation in vivo and predisposes CD4+ T cells to a Th1 hyperinflammatory response profile in vitro. However, the effect and underlying mechanisms of CIRP on Th17/Treg differentiation is still unclear. This study reveals the transcriptomic changes of mouse Naïve CD4+ T cells induced by Recombinant Mouse CIRP (rmCIRP) in vitro.

ORGANISM(S): Mus musculus

PROVIDER: GSE234044 | GEO | 2023/06/30

REPOSITORIES: GEO

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