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CTLA-4 tail fusion enhances CAR-T anti-tumor immunity [bulk RNA-seq]

ABSTRACT: To gain further insight into how CCT fusion engineering impacts their function, we characterized CAR-T cells using transcriptome profiling. We performed mRNA-seq from all four groups of CAR-T cells, either without stimulation (baseline) or with 2 rounds of NALM6GL stimulation. For CAR-T cells that were cocultured with 2 rounds of NALM6GL cells, we sorted the pure CAR-T populations (CAR+; GFP-) before subjecting them to RNA sequencing

ORGANISM(S): Homo sapiens

PROVIDER: GSE234306 | GEO | 2023/06/09

REPOSITORIES: GEO

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