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Gene expression analysis of hPSC derived macrophages (iMacs) co-cultured with hepatic cells

ABSTRACT: Purpose: to analyze change in gene expression of hPSC derived macrophages upon co-culture with hepatic cells including Huh7 and primary human hepatocytes Methods: SMART-seq2 amplified polyA RNA from sorted iMacs in the co-cultures. Results: the transcriptome of iMacs changed after co-culture with Huh7 cells or pHHs, and changed after the HCV infection of the co-cultured Huh7 cells. Conclusions: the gene expression profiles of co-cultured iMacs indicated that the culture conditions and the microenvironments could reprogrammed iMacs to adopt tissue-specific features and perform specifc functions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234572 | GEO | 2024/05/23

REPOSITORIES: GEO

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