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Gene expression analysis of hPSC-derived macrophages (iMACs) encountering Streptococcus pneumoniae.

ABSTRACT: Purpose: to analyze gene expression changes of iMACs encountering S. pneumoniae. Methods: SMART-seq2 amplified polyA RNA from sorted iMACs in the co-cultures. Results: the transcriptome of iMACs changed after encountering S. pneumoniae. Conclusions: the gene expression profiles of S. pneumoniae stimulated iMACs indicated iMACs undergoing inflammatory response and the immune response was distinct with iMACs encountering other pathogens such as HCV or SARS-CoV-2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE253876 | GEO | 2024/05/23

REPOSITORIES: GEO

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