Assessment of the molecular mechanism associated with osteogenic and angiogenic differentiation induced by FeMnSi scaffold
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ABSTRACT: To investigate the molecular mechanism underlying osteogenic and angiogenic differentiation induced by the De-HA scaffold, we conducted an in-depth gene microarray analysis on day 3 of MC3T3-E1 culture. We found that De-HA could enhance the transcription of osteogenic and angiogenic genes by activating FAK and downstream MAPK/ERK signaling to induce MC3T3-E1 differentiation. More importantly, our findings indicated that EGFR, a kind of transmembrane glycoprotein, played a key role in the osteogenic differentiation of MC3T3-E1, suggesting that the activation of the FAK/MAPK/ERK signaling cascade might be driven by EGFR.
ORGANISM(S): Mus musculus
PROVIDER: GSE235166 | GEO | 2023/06/20
REPOSITORIES: GEO
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