Transcriptomics

Dataset Information

0

Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain


ABSTRACT: While TGF-β signaling is essential for microglial function, the cellular source of TGF-β ligand and its spatial regulation remains unclear in adult CNS. Our data supports that microglia but not astrocytes or neurons are the primary producers of TGF-β1 ligands needed for microglial homeostasis. Microglia-Tgfb1 KO leads to activation of microglia featuring a dyshomeostatic transcriptomic profile that resembles disease-associated microglia (DAMs), injury-associated microglia, and aged microglia, suggesting that microglial self-produced TGF-β1 ligands are important in the adult CNS. Interestingly, astrocytes in the MG-tgfb1 iKO mice show a transcriptome profile that is closely aligned with A1-like astrocytes. Additionally, using sparse mosaic single cell microglia KO of TGF-β1 ligand we established an autocrine mechanism for TGF-β signaling. Importantly MG-Tgfb1 inducible KO mice show cognitive deficits, supporting that precise spatial regulation of TGF-β1 ligand derived from microglia is critical for the maintenance of brain homeostasis and normal cognitive function in the adult brain.

ORGANISM(S): Mus musculus

PROVIDER: GSE236032 | GEO | 2023/08/08

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-07-08 | GSE48579 | GEO
2013-07-11 | E-GEOD-43808 | biostudies-arrayexpress
2015-11-04 | E-GEOD-74614 | biostudies-arrayexpress
2010-10-05 | E-GEOD-18602 | biostudies-arrayexpress
2019-04-03 | GSE112604 | GEO
2009-02-28 | E-GEOD-9892 | biostudies-arrayexpress
2013-02-28 | E-GEOD-26532 | biostudies-arrayexpress
2014-07-01 | E-GEOD-49079 | biostudies-arrayexpress
2014-11-12 | GSE51617 | GEO
2014-11-12 | GSE51622 | GEO