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Single cell transcriptional analysis of regenerating parietal cells (PCs) in murine gastric epithelium recovering from Diphtheria toxin injury

ABSTRACT: Highly specialized, acid-secreting PCs are one of many epithelial lineages that line the gastric epithelium. Even though PCs are functionally and structurally distinct from other lineages in the stomach, the molecular mechanisms that govern their specification and maturation from the gastric stem cells are relatively unknown. We used single cell RNA sequencing (scRNA-seq) to construct a transcriptional profile for regenerating PCs and identify candidate regulators of PC fate specification and maturation.

ORGANISM(S): Mus musculus

PROVIDER: GSE236098 | GEO | 2024/05/01

REPOSITORIES: GEO

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