Recombinant IL-1 RA in human Chronic lymphocytic leukemia cells in vitro
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ABSTRACT: Inflammatory factors that activate NFkB play an important role in the pathogenesis of chronic lymphocytic leukemia (CLL) but are not addressed specifically by current therapies. Interleukin-1 (IL-1) is a master-regulator of inflammation that is inhibited safely in humans by the IL-1 receptor antagonist anakinra. Anakinra (K) was found to inhibit NFkB activity in CLL cells in an IL-1 receptor independent manner and had properties of an intracellular anti-oxidant in vitro.
ORGANISM(S): Homo sapiens
PROVIDER: GSE236552 | GEO | 2023/10/04
REPOSITORIES: GEO
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