Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Identification of interleukin-4 (IL-4) targets in chronic lymphocytic leukemia (CLL)


ABSTRACT: Gene expression profiles of CLL cells and normal B cells (NBC) treated for 18 hr with 10 ng/ml IL-4, compared with culture with nothing (Ctrl) and the basal (Pre) samples. Patient CLL01 was also treated with IL-4 plus 5 mg/ml ERK activation inhibitor peptide I, or IL-4 plus 10 µM NFkB activation inhibitor, and IL-4 plus 100 mg/ml cyclic-pifithrin-α 23 CLL patients (10 Pre samples, 23 Ctrl samples, 23 IL-4 samples, 1 IL-4 plus ERK inhibitor sample, 1 IL-4 plus NFkB inhibitor sample, 1 IL-4 plus Pifithrin sample), 13 NBC (10 Pre samples, 10 Ctrl samples, 13 IL-4 samples)

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Parrado 

PROVIDER: E-GEOD-55288 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

The gene expression response of chronic lymphocytic leukemia cells to IL-4 is specific, depends on ZAP-70 status and is differentially affected by an NFκB inhibitor.

Ruiz-Lafuente Natalia N   Alcaraz-García María-José MJ   Sebastián-Ruiz Silvia S   Gómez-Espuch Joaquín J   Funes Consuelo C   Moraleda José-María JM   García-Garay María-Carmen MC   Montes-Barqueros Natividad N   Minguela Alfredo A   Álvarez-López María-Rocío MR   Parrado Antonio A  

PloS one 20141003 10


Interleukin 4 (IL-4), an essential mediator of B cell development, plays a role in survival of chronic lymphocytic leukemia (CLL) cells. To obtain new insights into the function of the IL-4 pathway in CLL, we analyzed the gene expression response to IL-4 in CLL and in normal B cells (NBC) by oligonucleotide microarrays, resulting in the identification of 232 non-redundant entities in CLL and 146 in NBC (95 common, 283 altogether), of which 189 were well-defined genes in CLL and 123 in NBC (83 co  ...[more]

Similar Datasets

2014-10-06 | GSE55288 | GEO
2015-06-15 | E-GEOD-62137 | biostudies-arrayexpress
2015-06-15 | GSE62137 | GEO
2023-10-04 | GSE236552 | GEO
2023-10-04 | GSE236606 | GEO
2023-02-16 | GSE197662 | GEO
| PRJNA219743 | ENA
2023-01-13 | GSE216458 | GEO
2015-07-23 | GSE71231 | GEO
2009-03-03 | E-GEOD-15029 | biostudies-arrayexpress