Transcriptomics

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Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors


ABSTRACT: Topoisomerase I (Top1) relaxes both positive and negative supercoilings by producing transient Top1 cleavage complexes (Top1cc). Several studies have suggested the implication of Top1 in splicing. Here, we tested the implication of Top1cc in splicing at the global genome level in human carcinoma cells to determine whether Top1 inhibition selectively affects particular families of genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE23677 | GEO | 2011/07/22

SECONDARY ACCESSION(S): PRJNA130805

REPOSITORIES: GEO

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